ABL1 gene deletion without BCR/ABL1 rearrangement in a young adolescent with precursor B-cell acute lymphoblastic leukemia: clinical study and literature review

作者：Kim Min Jin; Yoon Hoi Soo; Lim Gayoung; Kim So Young; Lee Hee Joo; Suh Jin Tae; Lee Juhie; Lee Woo In; Park Tae Sung^*

来源：Cancer Genetics and Cytogenetics, 2010, 196(2): 184-188.

DOI：10.1016/j.cancergencyto.2009.09.018

Entire ABL1 gene deletion without BCR/ABL1 rearrangement is a rare phenomenon, with only four cases previously reported. Here we describe a fifth case of ABL1 deletion without BCR/ABL1 rearrangement in an adolescent patient with precursor B-cell lymphoblastic leukemia (B-ALL) and review the relevant literature. It is not clear how ABL1 deletion affects leukemogenesis; however, it is plausible that ABL1 deletion without BCR/ABL1 rearrangement is a rare but recurrent genetic abnormality in precursor B-ALL patients. Further studies are needed to evaluate the extent of the submicroscopic defects in chromosome 9 including ABL1 gene deletion, as well as treatment response and prognosis in long-term follow-up of such patients.

• 出版日期2010-1-15