A noncovalent, fluoroalkyl coating monomer for phosphonate-covered nanoparticles

作者：Li Vincent; Chang Andy Y; Williams Travis J^*

来源：Tetrahedron, 2013, 69(36): 7741-7745.

DOI：10.1016/j.tet.2013.05.092

• Theranostic
• Gold nanoparticle
• Surfaces
• Relaxivity
• Fluorine

Gadolinium-containing phosphonate-coated gold nanoparticles were prepared and then non-covalently coated with an amphiphilic fluorous monomer. The monomer spontaneously self-assembles into a noncovalent monolayer shell around the particle. The binding of the shell utilizes a guanidinium phosphonate interaction analogous to the one exploited by the Wender molecular transporter system. Particle shell binding was characterized by a 27% decrease in F-19 T-1 of the fluorous shell upon exposure to the paramagnetic gadolinium in the particle and a corresponding increase in hydrodynamic diameter from 3 nm to 4 nm. Interestingly, a much smaller modulation of F-19 T-1 is observed when the shell monomer is treated with a phosphonate-free particle. By contrast, the phosphonate-free particle is a much more relaxive H-1 T-1 agent for water. Together, these observations show that the fluoroalkylguanidinium shell binds selectively to the phosphonate-covered particle. The system's relaxivity and selectivity give it potential for use in F-19 based nanotheranostic agents.

• 出版日期2013-9-9