Air-Assisted 2-Oxo-Driven Dehydrogenative alpha,alpha-Diamination of 2-Oxo Aldehydes to 2-Oxo Acetamidines

作者:Kumar Atul; Battini Narsaiah; Kumar Raju Ranjith; Athimoolam S; Ahmed Qazi Naveed
来源:European Journal of Organic Chemistry, 2016, 2016(20): 3344-3348.
DOI:10.1002/ejoc.201600587

摘要

An air-assisted, functional-group-driven, mild, additive-free, three-component synthetic approach to different 2-oxo acetamidines from 2-oxo aldehydes, secondary amines, and anilines was successfully developed. Mechanistically, the transformation proceeds through a highly unstable system ((RCOCHNN2)-N-1) that rearranges at room temperature and undergoes air-assisted dehydrogenation to different 2-oxo acetamidines.

  • 出版日期2016-7

全文