Detection of Favorable Oral Cephalosporin-Clavulanate Interactions by In Vitro Disk Approximation Susceptibility Testing of Extended-Spectrum- Beta-Lactamase-Producing Members of the Enterobacteriaceae

作者：Campbell Jennifer D; Lewis James S II; McElmeel M Leticia; Fulcher Letitia C; Jorgensen James H^*

来源：Journal of Clinical Microbiology, 2012, 50(3): 1023-1026.

DOI：10.1128/JCM.06248-11

Extended-spectrum-beta-lactamase (ESBL)-producing members of the Enterobacteriaceae are often resistant to multiple drug classes, making therapy of urinary infections with oral antibiotics difficult. Previously it was shown that amoxicillin-clavulanate can provide clavulanate inhibition of ESBLs and protect an oral cephalosporin present in combination when tested by broth microdilution. This study has shown that disk approximation testing could detect favorable cephalosporin-clavulanate interactions among a group of 101 previously characterized members of the Enterobacteriaceae with CTX-M, SHV, or TEM ESBLs.

• 出版日期2012-3