Mapping biological behaviors by application of longer-lived positron emitting radionuclides

作者：Zhou Yang; Baidoo Kwamena E; Brechbiel Martin W^*

来源：Advanced Drug Delivery Reviews, 2013, 65(8): 1098-1111.

DOI：10.1016/j.addr.2012.10.012

• Immuno-PET
• Radioimmunoimaging
• Monoclonal antibodies
• Oncology
• Y-86
• Zr-89
• I-124
• Cu-64

With the technological development of positron emission tomography (PET) and the advent of novel antibody-directed drug delivery systems, longer-lived positron-emitting radionuclides are moving to the forefront to take important roles in tracking the distribution of biotherapeutics such as antibodies, and for monitoring biological processes and responses. Longer half-life radionuclides possess advantages of convenient on-site preparation procedures for both clinical and non-clinical applications. The suitability of the long half-life radionuclides for imaging intact monoclonal antibodies (mAbs) and their respective fragments, which have inherently long biological half-lives, has attracted increased interest in recent years. In this review, we provide a survey of the recent literature as it applies to the development of nine-selected longer-lived positron emitters with half-lives of 9-140 h (e.g., I-124, Cu-64, Y-86 and Zr-89), and describe the biological behaviors of radionuclide-labeled mAbs with respect to distribution and targeting characteristics, potential toxicities, biological applications, and clinical translation potentials. Published by Elsevier B.V.

• 出版日期2013-7