Amidines for Versatile Ruthenium( II)- Catalyzed Oxidative C-H Activations with Internal Alkynes and Acrylates

作者：Li Jie; John Michael; Ackermann Lutz^*

来源：Chemistry - A European Journal, 2014, 20(18): 5403-5408.

DOI：10.1002/chem.201304944

• alkenylation
• alkynes
• annulation
• CH activation
• reaction mechanisms
• ruthenium

Cationic ruthenium complexes derived from KPF6 or AgOAc enabled efficient oxidative CH functionalizations on aryl and heteroaryl amidines. Thus, oxidative annulations of diversely decorated internal alkynes provided expedient access to 1-aminoisoquinolines, while catalyzed CH activations with substituted acrylates gave rise to structurally novel 1-iminoisoindolines. The powerful ruthenium(II) catalysts displayed a remarkably high site-, regio- and, chemoselectivity. Therefore, the catalytic system proved tolerant of a variety of important electrophilic functional groups. Detailed mechanistic studies provided strong support for the cationic ruthenium(II) catalysts to operate by a facile, reversible CH activation.

• 出版日期2014-4-25