Vitamin A Deficiency Promotes Inflammation by Induction of Type 2 Cytokines in Experimental Ovalbumin-Induced Asthma Murine Model

作者：Cui, Weiwei; Zhang, Peng; Gu, Jingmin; Tian, Yuan; Gao, Xiuzhu; Liu, Yaqing; Jin, Zheng; Yan, Dongmei; Zhu, Xun^*; Li, Dong^*

来源：Inflammation, 2016, 39(5): 1798-1804.

DOI：10.1007/s10753-016-0415-2

• vitamin A
• asthma
• cytokines
• inflammation

Vitamin A (VA) deficiency is one of the most common malnutrition conditions. Recent reports showed that VA plays an important role in the immune balance; lack of VA could result in enhanced type 2 immune response characterized by increased type 2 cytokine production and type 2 innate lymphoid cell infiltration and activation. Type 2 immune response plays protective role in anti-infection but plays pathological role in asthmatic disease. In order to investigate the role of VA in the asthmatic disease, we used ovalbumin-induced asthma murine model and observed the pathological changes between mouse-received VA-deficient and VA-sufficient diets. We also measured the type 2 cytokine expressions to reveal the potential mechanism. Our results showed that VA deficiency exacerbates ovalbumin-induced lung inflammation and type 2 cytokine productions. Thus, VA deficiency, or malnutrition in further extent, may contribute to the increasing prevalence of asthma.

• 出版日期2016-10
• 单位吉林大学