Stability of niosomes with encapsulated vitamin D-3 and ferrous sulfate generated using a novel supercritical carbon dioxide method

作者：Wagner Michael E^*; Spoth Katherine A; Kourkoutis Lena F; Rizvi Syed S H

来源：Journal of Liposome Research, 2016, 26(4): 261-268.

DOI：10.3109/08982104.2015.1088868

• Iosome
• micronutrient encapsulation
• storage stability
• supercritical CO2

Niosomes were prepared using a novel supercritical carbon dioxide based method to simultaneously encapsulate ferrous sulfate and vitamin D-3 as hydrophilic and hydrophobic cargo, respectively. Vesicle particle size was determined to be bimodal with peak diameters of 1.44 +/- 0.16m and 7.21 +/- 0.64m, with the smaller peak comprising 98.8% of the total niosomal volume. Encapsulation efficiency of ferrous sulfate was 25.1 +/- 0.2% and encapsulation efficiency of vitamin D-3 was 95.9 +/- 1.47%. Physical stability of the produced niosomes was assessed throughout a storage period of 21 days. Niosomes showed good physical stability at 20 degrees C, but storage at 4 degrees C showed an initial burst release, indicating possible rupture of the niosomal membrane. The Korsmeyer-Peppas equation was used to model the release of ferrous sulfate over time at both storage temperatures.

• 出版日期2016-12