An alternative approach to the synthesis of new pyrimido[5 ',4 ':5,6][1,4]thiazino[2,3-b]quinoxaline derivatives

作者：Bakavoli Mehdi^*; Eshghi Hosein; Azizollahi Hamid; Saberi Sattar; Akbarzadeh Marziyeh

来源：Journal of Chemical Research, 2015, 39(3): 174-176.

DOI：10.3184/174751915X14243473376411

• synthesis of pyrimido[5 ',4 ':5,6][1,4]thiazine
• quinoxaline
• secondary amines
• intramolecular cyclisation
• intramolecular cyclisation

An alternative approach to the synthesis of a series of new pyrimido[5',4':5,6][1,4]thiazino[2,3-b] quinoxaline derivatives is described. Reaction of 5-bromo-2,4-dichloro-6-methylpyrimidine and 3-aminoquinoxaline-2-thiol leads to the key intermediate 3-[(5-bromo-2-chloro-6-methylpyrimidin-4-yl)thio]quinoxalin-2-amine. This intermediate can be transformed into the title ring systems by subsequent treatment either with secondary amines followed by intramolecular cyclisation or initial intramolecular cyclisation with subsequent reaction with secondary amines.

• 出版日期2015-3