科研之友
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摘要
Background: Atherosclerosis is the physiological basis of several types of cardiovascular and cerebrovascular diseases. The traditional Chinese traditional herb XinMaiJia (XMJ) has blood lipid-regulating and anti-lipid peroxidation effects. Purpose: To investigate the therapeutic effects and possible mechanism of XMJ on atherosclerosis in rats. Methods: Intraperitoneal injection of Vitamin D, high-forage feeding, and balloon injury were adopted to establish the atherosclerosis model in rats. The rats were administrated with high-, medium-, and low-dosage Zhibituo and XMJ as well as a control medicine. The blood plasma levels of lipids, relevant inflammatory factor levels, and oxidative stress indicators were determined. The expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in vascular smooth muscle cells was determined. Results: XMJ reduced the levels of plasma cholesterol, triglyceride, and low-density lipoprotein in atherosclerotic rats and increased the levels of glutamate, high-density lipoprotein, and apolipoprotein. After treatment with XMJ, the plasma levels of nitric oxide and superoxide dismutase markedly increased, and the level of malondialdehyde greatly decreased compared with those in the model group (P < 0.05). In addition, XMJ reduced the plasma levels of intercellular adhesion factor-1, vascular cell adhesion factor-1, interleukin-1, interleukin-6, matrix metalloproteinase-2, and tissue inhibitor of metalloproteinase-2, while reducing the content of cytokine nuclear factor-kappa B and expression of LOX-1. Conclusion: XMJ may have antiinflammatory and antioxidative effects on atherosclerosis in rats.
- 出版日期2016
- 单位新乡医学院
