Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor

作者：Keddie Neil S; Ye Yulin; Aslam Tashfeen; Luyten Tomas; Bello Davide; Garnham Clive; Bultynck Geert; Galione Antony; Conway Stuart J^*

来源：Chemical communications, 2011, 47(1): 242-244.

DOI：10.1039/c0cc03003a

The syntheses of four D-myo-inositol 1,4,5-trisphosphate (InsP(3)) derivatives, incorporating phosphate bioisosteres at the 5-position, are reported. The methyl phosphate ester and sulfate derivatives retain InsP(3) receptor (InsP(3)R) agonist activity; the compounds that possess a methylphosphonate or a carboxymethyl moiety are InsP(3)R antagonists.

• 出版日期2011