Antimicrobial and biodegradable PLGA medical sutures with natural grapefruit seed extracts

作者：Lee Hye Sun; Park So Hyun; Lee Jin Hyung; Jeong Bong Yong; Ahn Sang Kook; Choi Young Muk; Choi Doo Jin; Chang Jeong Ho^*

来源：Materials Letters, 2013, 95: 40-43.

DOI：10.1016/j.matlet.2012.12.090

• Suture
• Caffeic acid phenethyl ester
• Antimicrobial activity
• Biocompatibility
• Controlled release

This work demonstrates the development of novel antimicrobial and biodegradable suture coated by natural extract from grape fruit. The natural extract is loaded to PLGA suture and their optimum conditions are determined as a function of soaking time, loaded volume, and releasing time. Furthermore, the evaluation of antibacterial effect was achieved by Staphylococcus aureus and Escherchia DH5 alpha with the used amounts and released time. The cell growth was calculated for several days through 2 months. The physicochemical properties of antimicrobial and biodegradable PLGA suture are demonstrated.

• 出版日期2013-3-1