MAP kinase cascades regulating axon regeneration in C. elegans

作者：Pastuhov Strahil Iv^*; Hisamoto Naoki; Matsumoto Kunihiro

来源：Proceedings of the Japan Academy Series B-Physical and Biological Sciences, 2015, 91(3): 63-75.

DOI：10.2183/pjab.91.63

• MAP kinase
• axon regeneration
• Caenorhabditis elegans

Mitogen-activated protein kinase (MAPK) signaling cascades are activated by diverse stimuli such as growth factors, cytokines, neurotransmitters and various types of cellular stress. Our evolving understanding of these signal cascades has been facilitated by genetic analyses and physiological characterization in model organisms such as the nematode Caenorhabditis elegans. Genetic and biochemical studies in Caenorhabditis elegans have shed light on the physiological roles of MAPK cascades in the control of cell fate decision, neuronal function and immunity. Recently it was demonstrated that MAPK signaling is also important for axon regeneration in Caenorhabditis elegans, and the use of Caenorhabditis elegans as a model system has significantly advanced our understanding of the largely conserved molecular mechanisms underlying axon regeneration. This review summarizes our current understanding of the role and regulation of MAPK signaling in Caenorhabditis elegans axon regeneration.

• 出版日期2015-3