An immunoassay utilizing the DNA-coated polydiacetylene micelles as a signal generator

作者:Hoang Hoa Thi; Lee Taemin; Kim Byeong Su; Han Ki Cheol; Ahn Dae Ro*
来源:Bioorganic & Medicinal Chemistry Letters, 2013, 23(9): 2675-2678.
DOI:10.1016/j.bmcl.2013.02.087

摘要

Immunoassay is an important technique to detect the disease biomarkers and pathogenic biological agents which often present at low levels in clinical samples. To improve sensitivity of the immunoassay, here we described the DNA-coated, nano-sized micelles in which the DNA strands play a role as signal generators in an immunoassay. This micelle-based immunoassay was evaluated for quantitation of a liver cancer biomarker and the sensitivity of the method was compared with those of the conventional methods.

  • 出版日期2013-5-1

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