Assessment of complementary feeding of Canadian infants: effects on microbiome & oxidative stress, a randomized controlled trial

作者：Qasem Wafaa^*; Azad Meghan B; Hossain Zakir; Azad Elnaz; Jorgensen Sarah; Juan Sandra Castillo San; Cai Chenxi; Khafipour Ehsan; Beta Trust; Roberts L Jackson II; Friel James

来源：BMC Pediatrics, 2017, 17(1): 54.

DOI：10.1186/s12887-017-0805-0

• Breastfed infants
• Complementary feeding
• Iron fortified cereal
• Meat
• Microbiome

Background: The World Health Organization recommends exclusive breastfeeding until 6 months followed by introduction of iron-rich complementary foods (CFs). The aim of this study was to determine the impact of different iron-rich CFs on infant gut inflammation and microbiota.
Methods: Eighty-seven exclusively breastfed infants were randomly assigned to receive one of the following as their first CF: iron-fortified cereal (Cer), iron-fortified cereal with fruit (Cer + Fr), or meat (M). Urine and stool samples were collected to assess reactive oxygen species (ROS) generation, gut microbiota and inflammation.
Results: Fecal iron differed across feeding groups (p < 0.001); levels were highest in the Cer group and lowest in M group. A significant increase of fecal ROS formation (p < 0.002) after the introduction of CFs was observed, but did not differ across feeding groups. Fecal calprotectin increased within all groups after the introduction of CFs (p = 0.004). Gut microbiota richness increased after introduction of M or Cer + Fr. Regardless of feeding group, Coriobacteriaceae were positively correlated with ROS and Staphylococcaceae were negatively correlated with calprotectin.
Conclusions: Choice of first CF may influence gut inflammation and microbiota, potentially due to variations in iron absorption from different foods. Further research is warranted to fully characterize these associations and to establish implications for infant health.

• 出版日期2017-2-14