Dosimetric characteristics of PASSAG as a new polymer gel dosimeter with negligible toxicity

作者：Farhood Bagher; Abtahi Seyed Mohammad Mandi^*; Geraily Ghazale^*; Ghorbani Mehdi; Mandavi Seied Rabi; Zahmatkesh Mohammad Hasan

来源：Radiation Physics and Chemistry, 2018, 147: 91-100.

DOI：10.1016/j.radphyschem.2018.02.010

• Polymer gel dosimetery
• 2-Aaylamido-2-Methy-l-PropaneSulfonic acid sodium salt
• Toxicity
• PASSAG
• MRI

Despite many advantages of polymer gel dosimeters, their clinical use is only not realized now. Toxicity of polymer gel dosimeters can be considered as one of their main limitations for use in routine clinical applications. In the current study, a new polymer gel dosimeter is introduced with negligible toxicity. For this purpose, 2-Acrylamido-2-Methy-l-PropaneSulfonic acid (AMPS) sodium salt monomer was replaced instead of acrylamide monomer used in PAGAT gel dosimeter by using %6 T and %50 C to the gel formula and the new formulation is called PASSAG (Poly AMPS Sodium Salt and Gelatin) polymer gel dosimeter. The irradiation of gel dosimeters was carried out using a Co-60 therapy machine. MRI technique was used to quantify the dose responses of the PASSAG gel dosimeter. Then, the MRI responses (R-2) of the gel dosimeter was analyzed at different dose values, post-irradiation times, and scanning temperatures. The results showed that the new gel formulation has a negligible toxicity and it is also eco-friendly. In addition, carcinogenicity and genetic toxicity tests are negative for the monomer used in PASSAG. The radiological properties of PASSAG gel dosimeter showed that this substance can be considered as a soft tissue/water equivalent material. Furthermore, dosimetric evaluation of the new polymer gel dosimeter revealed an excellent linear R-2-dose response in the evaluated dose range (0-15 Gy). The R-2-dose sensitivity and dose resolution of PASSAG gel dosimeter were 0.081 s(-1)Gy(-1) (in 0-15 Gy dose range) and 1 Gy (in 0-10 Gy dose range), respectively. Moreover, it was shown that the R-2-dose sensitivity and dose resolution of the new gel dosimeter improves over time after irradiation. It was also found that the R-2 response of the PASSAG gel dosimeter has less dependency to the 18, 20, and 24 degrees C scanning temperature in comparison to that of room temperature (22 degrees C).

• 出版日期2018-6