Acylphenols and dimeric acylphenols from Myristica maxima Warb

作者：Othman Muhamad Aqmal; Sivasothy Yasodha; Looi Chung Yeng; Ablat Abdulwali; Mohamad Jamaludin; Litaudon Marc; Awang Khalijah

来源：Fitoterapia, 2016, 111: 12-17.

DOI：10.1016/j.fitote.2016.04.004

• Myristica maxima Warb
• Myristicaceae
• Dimeric acylphenols
• Acylphenols
• Prostate cancer
• DPPH free radical scavenging activity

Giganteone E (1), a new dimeric acylphenol was isolated as a minor constituent from the bark of Myristica maxima Warb. The structure of 1 was established on the basis of 1D and 2D NMR techniques and LCMSIT-TOF analysis. Malabaricones A-C (2-4), giganteones A and C (5 and 6), maingayones A and B (7 and 8), maingayic add B (9) and beta-sitosteryl oleate (10) were also characterized in this plant for the first time. Compound 10 was identified for the first time in the Myristicaceae. Compounds 2 and 5 were active against human prostate cancer cell lines, thus making this the first report on the prostate cancer inhibiting potential of acylphenols and dimeric acylphenols. Compounds 1, 4, 5, 7 and 8 exhibited potent DPPH free radical scavenging activity. This is the first report on their free radical scavenging capacity.

• 出版日期2016-6