A randomised, double-blind, placebo-controlled trial on the effect of Pycnogenol (R) on the climacteric syndrome in peri-menopausal women

作者：Yang Han Ming; Liao Mei Fen; Zhu Shu Yuan; Liao Mei Nan; Rohdewald Peter

来源：Acta Obstetricia et Gynecologica Scandinavica, 2007, 86(8): 978-985.

DOI：10.1080/00016340701446108

Background. French maritime pine bark extract (Pycnogenol (R)) was found to alleviate menstrual pain and reduce hyperactivity in clinical studies. These results suggest the possibility to observe positive effects in treating climacteric syndrome. Objective. Clinical investigation of the effect of Pycnogenol (R), French maritime pine bark extract, on the climacteric syndrome. Methods. Some 200 peri-menopausal women were enrolled in a double-blind, placebo-controlled study, and treated with Pycnogenol (R) (200 mg) daily. Climacteric symptoms were evaluated by the Women's Health Questionnaire ( WHQ), patients were checked for antioxidative status and routine chemistry. A total of 155 women completed the study. Results. All climacteric symptoms improved, antioxidative status increased and LDL/HDL ratio was favourably altered by Pycnogenol (R). No side effects were reported. Conclusion. Pycnogenol (R) may offer an alternative method to reducing climacteric symptoms without unwanted effects.

• 出版日期2007
• 单位河北医科大学