Differential Roles of Interleukin-17A and-17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses

作者：Ishigame Harumichi; Kakuta Shigeru; Nagai Takeshi; Kadoki Motohiko; Nambu Aya; Komiyama Yutaka; Fujikado Noriyuki; Tanahashi Yuko; Akitsu Aoi; Kotaki Hayato; Sudo Katsuko; Nakae Susumu; Sasakawa Chihiro; Iwakura Yoichiro^*

来源：Immunity, 2009, 30(1): 108-119.

DOI：10.1016/j.immuni.2008.11.009

Interleukin-17A (IL-17A) is a cytokine produced by T helper 17 (Th17) cells and plays important roles in the development of inflammatory diseases. Although IL-17F is highly homologous to IL-17A and binds the same receptor, the functional roles of this molecule remain largely unknown. Here, we demonstrated with II17a(-/-), II17f(-/-), and II17a(-/-)II17f(-/-) mice that IL-17F played only marginal roles, if at all, in the development of delayed-type and contact hypersensitivities, autoimmune encephalomyelitis, collagen-induced arthritis, and arthritis in II1rn(-/-) mice. In contrast, both IL-17F and IL-17A were involved in host defense against mucoepithelial infection by Staphylococcus aureus and Citrobacter rodentium. IL-17A was produced mainly in T cells, whereas IL-17F was produced in T cells, innate immune cells and epithelial cells. Although only IL-17A efficiently; induced cytokines in macrophages, both cytokines activated epithelial innate immune responses. These observations indicate that IL-17A and IL-17F have overlapping yet distinct roles in host immune and defense mechanisms.

• 出版日期2009-1-16
• 单位河北医科大学