Association between the human papillomavirus, bacterial vaginosis and cervicitis and the detection of abnormalities in cervical smears from teenage girls and young women

作者：Assis Caixeta Rodrigo Cesar; Ribeiro Andrea Alves; Segatti Kelly Deyse; Saddi Vera Aparecida; Figueiredo Alves Rosane Ribeiro; dos Santos Carneiro Megmar Aparecida; Rabelo Santos Silvia Helena^*

来源：Diagnostic Cytopathology, 2015, 43(10): 780-785.

DOI：10.1002/dc.23301

• HPV
• bacterial vaginosis
• cervicitis
• adolescent girls
• young adults

BackgroundHuman papillomavirus (HPV) infection, bacterial vaginosis (BV), and cervicitis may play a role in the presence of cytological abnormalities in female adolescents and young women. This study aimed to estimate the prevalence of HPV, BV and cervicitis in female adolescents and young women and evaluate whether these conditions are associated with a finding of cytological abnormalities in cervical smears.
MethodsCervical smears were screened using the conventional method and HPV-DNA detection was performed by PGMY-PCR. BV was defined as 20% clue cells in cervical smears. Cervicitis was assessed by counting leukocytes in five non-adjacent microscopic fields at 1000x magnification. Odds ratios and 95% confidence intervals were calculated.
ResultsThe study analyzed 251 samples, with cytological abnormalities being found in 9.5% (24/251). Atypical squamous cells of undetermined significance (50.0%) and low-grade squamous intraepithelial lesions (29.1%) were the most common findings. HPV, BV and cervicitis were found in 44.2% (111/251), 41.0% (103/251) and 83.2% (209/251) of cases, respectively. Of the variables investigated, BV and an abnormal cytological diagnosis were independently associated with HPV positivity. Cytological abnormalities were significantly associated with a finding of HPV and BV in the same woman, and also with a simultaneous finding of HPV, BV and cervicitis; however, the independent association of these combined variables did not remain significant in the multivariate analysis.
ConclusionsBV and cytological abnormalities were independently associated with HPV infection in female adolescents and young women. Diagn. Cytopathol. 2015;43:780-785.

• 出版日期2015-10