An efficient approach to new dihydroxyquinolizidines

作者：Tite Tony; Jacquelin Feimida; Bischoff Laurent^*; Fruit Corinne; Marsais Francis

来源：Tetrahedron: Asymmetry , 2010, 21(16): 2032-2036.

DOI：10.1016/j.tetasy.2010.05.036

Using D-glyceraldehyde acetonide as a starting material, a four-step synthesis of enantiomerically pure 3,4-dihydroxyquinolizidines is described. The key steps of the synthesis consist of a Mitsunobu ring-closing reaction and the subsequent reduction of a pyridinium ring.

• 出版日期2010-8-23