An efficient synthesis of pyrido-imidazodiazepinediones

作者:Arama Dominique P; Lisowski Vincent; Scarlata Eliana; Fulcrand Pierre; Maillard Ludovic T; Martinez Jean; Masurier Nicolas*
来源:Tetrahedron Letters, 2013, 54(11): 1364-1367.
DOI:10.1016/j.tetlet.2012.12.087

摘要

We herein report the synthesis of a series of 12 optically pure 3,4-dihydro-1H-pyrido-[1',2':1,21-imidazo[4,5-d][1,31diazepine-2,5-diones, which form a new family of azaheterocycle-fused [1,3]diazepines. The key step of the synthesis consists in a selective C-acylation of 2-amino-imidazo[1,2-a]pyridine by various natural amino-acids, followed by an intracarbonylation reaction.

  • 出版日期2013-3-13

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