科研之友
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摘要
objectives: malnutrition is an independent predictor of death in idiopathic dilated cardiomyopathy. an analysis was performed of the impact of l-carnitine supplementation on the nutritional status and echocardiogram parameters of children with idiopathic dilated cardiomyopathy. methods: this was an open label cohort of 11 patients who received l-carnitine (100 mg/kg/day) plus the conventional medical treatment, compared with 40 controls, matched for gender and age. the l-carnitine group was weighed 118 times and the controls 264 times. additionally, the l-carnitine group underwent 65 two-dimensional echocardiograms and the controls 144. chi-square, student%26apos;s t test, pearson correlation and anova were calculated with alpha = 0.05. results: for the l-carnitine group: age at presentation = 3.82 years old, 72.7% (p = 0.033) were females younger than 2 years and 90.9% (p = 0.0001) were in functional classes iii and iv. there were no deaths during this period. at presentation, no differences were observed in weight percentile (31.2㊣8.74 vs. 19.6㊣21.2) (p = 0.29) or z score (-0.68㊣1.05 vs. -1.16㊣0.89) (p = 0.24). increases were observed in both the percentile (p = 0.026) and z score (p = 0.033) after the introduction of l-carnitine. at presentation, there were no differences in ejection fraction (54.9%㊣3.8 vs. 49.3%㊣6.6) (p = 0.19), but lv mass/bsa were greater in the l-carnitine group (169.12 g/m2㊣26.24 vs. 110.67 g/m2㊣15.62) (p = 0.0005). after the introduction of l-carnitine an increase in ejection fraction (48.3㊣7 to 67.2㊣7) (p = 0.044) was observed. lv mass/bsa decreased (164.29g/m2㊣28.14 to 110.88g/m2㊣28.88), but without significance (p = 0.089) conclusion: in children with idiopathic dilated cardiomyopathy, supplementation of l-carnitine may be helpful for nutritional and echocardiographic improvement.
- 出版日期2005
