A green, isocyanide-based three-component reaction approach for the synthesis of multisubstituted ureas and thioureas

作者：Angyal Aniko; Demjen Andras; Wolfling Janos; Puskas Laszlo G; Kanizsai Ivan^*

来源：Tetrahedron Letters, 2018, 59(1): 54-57.

DOI：10.1016/j.tetlet.2017.11.053

• Multicomponent reaction
• Isocyanide
• Urea
• Thiourea
• N-chloro amine

A one-pot, isocyanide based multicomponent protocol was presented starting from secondary amines towards (thio)urea derivatives and utilized for the construction of a diverse 27-membered chemical library. Following a green compatible microwave assisted condition, the formed N,N'-multisubstituted (thio)ureas were obtained in up to 85% yield.

• 出版日期2018-1-3