Diversity and convergence in the mechanisms establishing L/R asymmetry in metazoa

作者：Coutelis Jean Baptiste; Gonzalez Morales Nicanor; Geminard Charles; Noselli Stephane^*

来源：EMBO Reports, 2014, 15(9): 926-937.

DOI：10.15252/embr.201438972

• L/R asymmetry
• symmetry breaking
• directional morphogenesis
• evolution, invertebrates
• vertebrates

Differentiating left and right hand sides during embryogenesis represents a major event in body patterning. Left-Right (L/R) asymmetry in bilateria is essential for handed positioning, morphogenesis and ultimately the function of organs (including the brain), with defective L/R asymmetry leading to severe pathologies in human. How and when symmetry is initially broken during embryogenesis remains debated and is a major focus in the field. Work done over the past 20 years, in both vertebrate and invertebrate models, has revealed a number of distinct pathways and mechanisms important for establishing L/R asymmetry and for spreading it to tissues and organs. In this review, we summarize our current knowledge and discuss the diversity of L/R patterning from cells to organs during evolution.

• 出版日期2014-9