A cross-talk network that facilitates tumor virotherapy

作者:Bronisz Agnieszka*; Chiocca E Antonio
来源:Nature Medicine, 2015, 21(5): 426-427.
DOI:10.1038/nm.3857

摘要

To target and kill cancer cells, oncolytic viruses exploit signaling pathways that promote tumor growth. A new study shows that the cancer stromal fibroblast factor FGF2 is a crucial component of a tumor-TGF-beta axis that renders cancer cells sensitive to virus infection.

  • 出版日期2015-5

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