A novel paclitaxel-loaded poly(D, L-lactide-co-glycolide)-Tween 80 copolymer nanoparticle overcoming multidrug resistance for lung cancer treatment

作者：Yuan, Xun; Ji, Wenxiang; Chen, Si; Bao, Yuling; Tan, Songwei; Lu, Shun; Wu, Kongming; Chu, Qian^*

来源：International Journal of Nanomedicine, 2016, 11: 2119-2131.

DOI：10.2147/IJN.S92271

• poly(D,L-lactide-co-glycolide)
• Tween 80
• nanoparticle
• drug resistance
• lung cancer

Drug resistance has become a main obstacle for the effective treatment of lung cancer. To address this problem, a novel biocompatible nanoscale package, poly(D,L-lactide-co-glycolide)-Tween 80, was designed and synthesized to overcome paclitaxel (PTX) resistance in a PTX-resistant human lung cancer cell line. The poly(D,L-lactide-co-glycolide) (PLGA)-Tween 80 nanoparticles (NPs) could efficiently load PTX and release the drug gradually. There was an increased level of uptake of PLGA-Tween 80 in PTX-resistant lung cancer cell line A549/T, which achieved a significantly higher level of cytotoxicity than both PLGA NP formulation and Taxol (R). The in vivo antitumor efficacy also showed that PLGA-Tween 80 NP was more effective than Taxol (R), indicating that PLGA-Tween 80 copolymer was a promising carrier for PTX in resistant lung cancer.

• 出版日期2016
• 单位上海交通大学; 华中科技大学