Aqueous Extracts of Liriope platyphylla Are Tightly-Regulated by Insulin Secretion from Pancreatic Islets and by Increased Glucose Uptake through Glucose Transporters Expressed in Liver Hepatocytes

作者：Kim Ji Eun; Nam So Hee; Choi Sun Il; Hwang In Sik; Lee Hye Ryun; Jang Min Ju; Lee Chung Yeol; Soon Hong Ju; Lee Hee Seob; Kim Hae Sung; Kang Byeong Cheol; Hong Jin Tae; Hwang Dae Youn^*

来源：Biomolecules & Therapeutics, 2011, 19(3): 348-356.

DOI：10.4062/biomolther.2011.19.3.348

• Liriope platyphylla
• Insulin
• Diabetes
• Glucose transporter
• Signaling pathway

Liriope platyphylla is a medical herb that has long been used in Korea and China to treat cough, sputum, neurodigenerative disorders, obesity and diabetes. The aims of this study were to study the antidiabetic effects of the aqueous extract of L. platyphylla (AEtLP) through pancreatic and extrapancreatic actions. AEtLP were orally administrated to ICR mice once a day for 7 days. Of three different concentrations of AEtLP, only 10% AEtLP were low toxic to liver, based on body weight and serum biochemical analyses. However, 10% AEtLP-treated mice displayed significant reduction of the glucose concentration and increased insulin concentration; no changes were noted using 5% and 15% AEtLP. Also, the increase of glucose transporter (Glut)-1 expression in liver was dependent on the concentration of AEtLP, and was regulated by the phosphorylation of Akt. The lowest expression of Glut-3 was observed in 15% AEtLP treated mice, followed by 10% AEtLP- and 5% AEtLP-treated mice. This pattern of Glut-3 expression was roughly in accord with the phosphorylation of c-Jun N-teminal kinase (JNK) in the mitogen-activated protein kinase (MAPK) pathway. Furthermore, a significant rise of the superoxide dismutase activity (SOD) was detected in AEtLP-treated mice. The findings suggest that AEtLP should be considered as a diabetes therapeutic candidate to induce insulin secretion from pancreatic beta-cells and glucose uptake in liver cells.

• 出版日期2011-7-31