The higher exercise intensity and the presence of allele I of ACE gene elicit a higher post-exercise blood pressure reduction and nitric oxide release in elderly women: an experimental study

作者：Santana Hugo A P; Moreira Sergio R; Neto Willson B; Silva Carla B; Sales Marcelo M; Oliveira Vanessa N; Asano Ricardo Y^*; Espindola Foued S; Nobrega Otavio T; Campbell Carmen S G; Simoes Herbert G

来源：BMC Cardiovascular Disorders, 2011, 11(1): 71.

DOI：10.1186/1471-2261-11-71

Background: The absence of the I allele of the angiotensin converting enzyme (ACE) gene has been associated with higher levels of circulating ACE, lower nitric oxide (NO) release and hypertension. The purposes of this study were to analyze the post-exercise salivary nitrite (NO(2)(-)) and blood pressure (BP) responses to different exercise intensities in elderly women divided according to their ACE genotype.
Methods: Participants (n = 30; II/ID = 20 and DD = 10) underwent three experimental sessions: incremental test - IT (15 watts workload increase/3 min) until exhaustion; 20 min exercise 90% anaerobic threshold (90% AT); and 20 min control session without exercise. Volunteers had their BP and NO(2)(-) measured before and after experimental sessions.
Results: Despite both intensities showed protective effect on preventing the increase of BP during post-exercise recovery compared to control, post-exercise hypotension and increased NO(2)(-) release was observed only for carriers of the I allele (p < 0.05).
Conclusion: Genotypes of the ACE gene may exert a role in post-exercise NO release and BP response.

• 出版日期2011-12-2