A radical mediated approach to the core structure of huperzine A

作者：Ward J; Caprio V^*

来源：Tetrahedron Letters, 2006, 47(4): 553-556.

DOI：10.1016/j.tetlet.2005.11.037

• huperzine A
• pyridylmethyl radicals
• selenation
• radical cyclisation

The synthesis of the core structure of huperzine A by cyclisation of 2-pyridylmethyl radicals is described. (2-Methylpyridin-3-yl)cyclohexenols are directly selenated at the benzylic position by deprotonation/selenation and the products undergo either 5-exo-trig or 6-exo-trig radical cyclisations giving access to hexahydroindenopyridines and the bicyclo[3.3.1]nonane core of huperzine A, respectively.

• 出版日期2006-1-23