A Phase II study of a histamine H-3 receptor antagonist GSK239512 for cognitive impairment in stable schizophrenia subjects on antipsychotic therapy

作者：Jarskog L Fredrik; Lowy Martin T; Grove Richard A^*; Keefe Richard S E; Horrigan Joseph P; Ball M Patricia; Breier Alan; Buchanan Robert W; Carter Cameron S; Csernansky John G; Goff Donald C; Green Michael F; Kantrowitz Joshua T; Keshavan Matcheri S; Laurelle Marc; Lieberman Jeffrey A; Marder Stephen R; Maruff Paul; McMahon Robert P; Seidman Larry J; Peykamian Margaret A

来源：Schizophrenia Research, 2015, 164(1-3): 136-142.

DOI：10.1016/j.schres.2015.01.041

• Schizophrenia
• Cognition
• Histamine H-3 antagonist
• CogState Schizophrenia Battery
• MATRICS Consensus Cognition Battery
• GSK239512

This Phase II exploratory study assessed GSK239512, a brain penetrant histamine H-3 receptor antagonist, versus placebo on cognitive impairment in 50 stable outpatients with schizophrenia. Subjects were randomized to placebo or GSK239512 for 7 weeks (4 weeks titration). GSK239512 was associated with a small positive effect size (ES) on the CogState Schizophrenia Battery (CSSB) Composite Score (ES = 0.29, CI = -0.40, 0.99) relative to placebo (primary endpoint). GSK239512's ES on CSSB domains were generally positive or neutral except Processing Speed, which favored placebo (ES = -0.46). Effects on the MATRICS Consensus Cognitive Battery were mostly neutral or favored placebo. GSK239512 was generally well tolerated with an adverse event profile consistent with the known class pharmacology. There was no evidence of overall beneficial effects of GSK239512 for CIAS in this population.

• 出版日期2015-5