A modular DNA origami-based enzyme cascade nanoreactor

作者：Linko Veikko; Eerikainen Marika; Kostiainen Mauri A^*

来源：Chemical communications, 2015, 51(25): 5351-5354.

DOI：10.1039/c4cc08472a

In this communication, we present a nanoscale reactor assembled from tuneable and spatially addressable tubular DNA origami units. We can controllably combine separate origami units equipped with glucose oxidase (GOx) and horseradish peroxidase (HRP), and demonstrate efficient GOx/HRP enzyme cascade reaction inside the tube. The reactor could be utilized as a nanoscale diagnostic tool, and modularity of the proposed system would further enable more complex reactions.

• 出版日期2015