Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates

作者：Greenberg Marc M^*

来源：Organic and Biomolecular Chemistry, 2007, 5(1): 18-30.

DOI：10.1039/b612729k

DNA damage is a double-edged sword. The modi. cations produced in the biopolymer are associated with aging, and give rise to a variety of diseases, including cancer. DNA is also the target of anti-tumor agents and the most generally used nonsurgical treatment of cancer, ionizing radiation. Agents that damage DNA produce a variety of radicals. Elucidating the chemistry of individual DNA radicals is challenging due to the availability of multiple reactive pathways and complexities inherent with carrying out mechanistic studies on a heterogeneous polymer. The ability to independently generate radicals and their metastable products at defined sites in DNA has greatly facilitated understanding this biologically important chemistry.

• 出版日期2007