Activity of T-Helper Cells in Patients with Primary Sjogren's Syndrome

作者：Sudzius Gintaras; Mieliauskaite Diana; Butrimiene Irena; Siaurys Almantas; Mackiewicz Zygmunt; Dumalakiene Irena^*

来源：In Vivo, 2013, 27(2): 263-268.

• Primary Sjogren's syndrome
• Th1
• Th2
• Th17
• Th17/Th1-like

Aim: To investigate the T-helper (Th1, Th2 and Th17) cell activity in the peripheral blood of patients with primary Sjogren's syndrome (pSS), non-Sjogren's sicca syndrome (nSS) and healthy controls.
Patients and Methods: Peripheral blood mononuclear cells from 34 pSS, 13 nSS patients and 13 healthy controls were stimulated, labeled for cluster of differentiation-4 (CD4), interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and IL-17A and analyzed by flow cytometry.
Results: The activities of Th1 and Th17 cells in patients with pSS were similar to those of the control group. The percentage of both IFN-gamma- and IL-17-producing Th17/Th1-like cells was significantly higher in the pSS, as compared to the control group, whereas that of Th2 cells was lower. A significant correlation was found between all Th-subset activities in the control group. However, in the pSS group, a correlation was found only between Th1 with Th2 and Th17 and Th17 with Th17/Th1 -like.
Conclusion: The imbalance in Th-subset activities in peripheral blood may play a role in the pathogenesis of pSS.

• 出版日期2013-4