Neonatal Brain Hemorrhage (NBH) of Prematurity: Translational Mechanisms of the Vascular-Neural Network

作者：Lekic Tim; Klebe Damon; Poblete Roy; Krafft Paul R; Rolland William B; Tang Jiping; Zhang John H^*

来源：Current Medicinal Chemistry, 2015, 22(10): 1214-1238.

DOI：10.2174/0929867322666150114152421

• Cerebral palsy
• experimental
• germinal matrix hemorrhage
• hydrocephalus
• mental retardation
• neonatal rats
• neurological dysfunction
• pathogenesis
• stroke

Neonatal brain hemorrhage (NBH) of prematurity is an unfortunate consequence of pre-term birth. Complications result in shunt dependence and long-term structural changes such as posthemorrhagic hydrocephalus, periventricular leukomalacia, gliosis, and neurological dysfunction. Several animal models are available to study this condition, and many basic mechanisms, etiological factors, and outcome consequences, are becoming understood. NBH is an important clinical condition, of which treatment may potentially circumvent shunt complication, and improve functional recovery (cerebral palsy, and cognitive impairments). This review highlights key pathophysiological findings of the neonatal vascular-neural network in the context of molecular mechanisms targeting the posthemorrhagic hydrocephalus affecting this vulnerable infant population.

• 出版日期2015