Macular Choroidal Thickness and Volume in Eyes With Angioid Streaks Measured by Swept Source Optical Coherence Tomography

作者：Ellabban Abdallah A; Tsujikawa Akitaka^*; Matsumoto Akiko; Ogino Ken; Hangai Masanori; Ooto Sotaro; Yamashiro Kenji; Akiba Masahiro; Yoshimura Nagahisa

来源：American Journal of Ophthalmology, 2012, 153(6): 1133-1143.

DOI：10.1016/j.ajo.2011.12.013

center dot PURPOSE: To study the mean choroidal thickness and volume of the macula in eyes with angioid streaks using swept source optical coherence tomography (OCT) in the 1050-nm wavelength range.
center dot DESIGN: Prospective case series.
center dot METHODS: The macular area of 39 eyes of 23 patients with angioid streaks and of 20 normal eyes of 20 matched controls (Group 1) was studied with a swept source OCT prototype system. Eyes with angioid streaks were classified into 1 of 4 groups: those without choroidal neovascularization (CNV) (Group 2); those with CNV that had no history of treatment (Group 3); those with CNV that had previously received only anti-vascular endothelial growth factor treatments (Group 4); and those with CNV that had previously received photodynamic therapy (Group 5). Using a raster scan protocol with 512 x 128 A-scans, we produced a macular choroidal thickness map (6 x 6 mm(2)).
center dot RESULTS: There were no significant differences in age, axial length, or refractive error among the 5 groups. Mean choroidal thickness of the macula in Group 2 (218.9 +/- 46.8 mu m) was as great as that in Group 1 (218.8 +/- 69.2 mu m). However, the macular choroidal thickness in Group 3 (119.7 +/- 49.2 mu m), Group 4 (140.1 +/- 64.9 mu m), and Group 5 (144.0 +/- 52.6 mu m) was significantly less than that of Group 1 (P < .05). There were no statistical differences between Groups 3 through 5. In each group, the choroid of the nasal quadrant was significantly thinner compared to that in other quadrants (P < .05).
center dot CONCLUSIONS: The choroid in eyes with angioid streaks without CNV was as thick as that in normal controls, but was significantly thinner in eyes with angioid streaks that had developed CNV. (Am J Ophthalmol 2012;153:1133-1143.

• 出版日期2012-6