Development of CNS multi-receptor ligands: Modification of known D-2 pharmacophores

作者：Etukala Jagan R; Zhu Xue Y; Eyunni Suresh V K; Onyameh Edem K; Ofori Edward; Bricker Barbara A; Kang Hye J; Huang Ping; Roth Bryan L; Ablordeppey Seth Y^*

来源：Bioorganic & Medicinal Chemistry, 2016, 24(16): 3671-3679.

DOI：10.1016/j.bmc.2016.06.011

• Multi-receptor targeting
• Dopamine receptor ligands
• Antipsychotic
• Pharmacophore
• CNS receptor

Several known D-2 pharmacophores have been explored as templates for identifying ligands with multiple binding affinities at dopamine and serotonin receptors considered as clinically relevant receptors in the treatment of neuropsychiatric diseases. This approach has resulted in the identification of ligands that target multiple CNS receptors while avoiding others associated with deleterious effects. In particular, compounds 11, 15 and 22 may have potential for further development as antipsychotic agents as they favorably interact with the clinically relevant receptors including D2R, 5-HT1AR, and 5-HT7R. We have also identified the pair of compounds 11 and 10 as high affinity D2R ligands with and without SERT binding affinities, respectively. These differential binding profiles endow the pair with the potential for evaluating SERT contributions to antipsychotic drug activity in animal behavioral models. In addition, compound 11 has no significant affinity for 5-HT2CR and binds only moderately to the H1R, suggesting it may not induce weight gain or sedation when used clinically. Taken together, compound 11 displays an interesting pharmacological profile that necessitates the evaluation of its functional and in vivo effects in animal models which are currently ongoing. Published by Elsevier Ltd.

• 出版日期2016-8-15