Direct synthesis of N-terminal thiazolidine-containing peptide thioesters from peptide hydrazides

作者：Sato Kohei^*; Tanaka Shoko; Yamamoto Kazuki; Tashiro Yosuke; Narumi Tetsuo; Mase Nobuyuki

来源：Chemical communications, 2018, 54(66): 9127-9130.

DOI：10.1039/c8cc03591a

We report a simple and promising synthetic method to oxidize peptide hydrazides containing N-terminal thiazolidine as a protected cysteine. This yields the corresponding thioester via a peptide azide without decomposition of the thiazolidine ring. The newly developed protocol was validated by the synthesis of the bioactive peptide LacZ.

• 出版日期2018-8-25