A modular approach to cyclic tetrapeptides related to histone deacetylase inhibition: synthesis of epi-microsporin A

作者：Mukherjee Jyoti Prasad; Sil Suman; Chattopadhyay Shital K^*

来源：Tetrahedron Letters, 2016, 57(7): 739-742.

DOI：10.1016/j.tetlet.2016.01.005

• alpha-Amino acid
• Cyclic peptide
• Macrocyclisation
• Cross metathesis
• Modular synthesis

A short new route to the unusual amino acid component (S)-2-amino-8-oxodecanoic acid (Aoda) of some important HDAC inhibitors has been developed using cross metathesis reaction as the key step. An extension of the study employing grafting of a macrocyclic scaffold through cross metathesis has proved to be highly efficient for the synthesis of an isomer of the cyclic tetrapeptide HDAC inhibitor microsporin.

• 出版日期2016-2-17