Antimicrobial Coumarins from the Stem Bark of Afraegle paniculata

作者：Tsassi Valerie Beatrice; Hussain Hidayat^*; Meffo Bouberte Yemele; Kouam Simeon F; Dongo Etienne; Schulz Barbara; Green Ivan R; Krohn Karsten

来源：Natural Product Communications, 2010, 5(4): 559-561.

• Afraegle paniculata
• Rutaceae
• 6 ',7 '-dimethyl-S-trans-marmin
• coumarin
• antimicrobial activity

Eight compounds were isolated from the stem bark of the plant Afraegle paniculata. One of them, a dimethyl ether of S-transmarmin (1), is reported as a new natural product. The structures were determined by comprehensive analyses of their ID and 2D NMR spectroscopic and HREIMS data. The remaining seven known compounds, identified by comparing their spectroscopic data with those reported in the literature, were S-trans-marmin (2), psoralene (3), bergaptene (4), imperatorin (5), 2-(4-hydroxy-3,5-dimethoxyphenyl)-3-hydroxymethyl-2,3-dihydro-1,4,5-trioxaphenanthren-6-one (6), xanthoxyletin (7), and P-sitosterol glucopyranoside. Preliminary studies indicated that compounds 2, 3, 5, and 7 showed potent antibacterial, fungicidal, and algicidal properties, while 6 showed only moderate algicidal property.

• 出版日期2010-4