Ubiquitylation of DNA polymerase lambda

作者：Markkanen Enni; van Loon Barbara; Ferrari Elena; Huebscher Ulrich

来源：FEBS LETTERS, 2011, 585(18): 2826-2830.

DOI：10.1016/j.febslet.2011.03.069

• DNA polymerase lambda
• Posttranslational modifications
• Regulation
• Oxidation damage
• Ubiquitylation

DNA polymerase (pol) lambda, one of the 15 cellular pols, belongs to the X family. It is a small 575 amino-acid protein containing a polymerase, a dRP-lyase, a proline/serine rich and a BRCT domain. Pol lambda shows various enzymatic activities including DNA polymerization, terminal transferase and dRP-lyase. It has been implicated to play a role in several DNA repair pathways, particularly base excision repair (BER), non-homologous end-joining (NHEJ) and translesion DNA synthesis (TLS). Similarly to other DNA repair enzymes, pol lambda undergoes posttranslational modifications during the cell cycle that regulate its stability and possibly its subcellular localization. Here we describe our knowledge about ubiquitylation of pol lambda and the impact of this modification on its regulation.

• 出版日期2011-9-16