A fatal case of acute exacerbation of interstitial lung disease in a patient with rheumatoid arthritis during treatment with tocilizumab

作者：Kawashiri Shin ya^*; Kawakami Atsushi; Sakamoto Noriho; Ishimatsu Yuji; Eguchi Katsumi

来源：Rheumatology International, 2012, 32(12): 4023-4026.

DOI：10.1007/s00296-010-1525-z

• Tocilizumab
• Rheumatoid arthritis
• Interstitial lung disease
• Pneumocystis pneumonia

A 68-year-old man, who was a patient with established rheumatoid arthritis (RA) with RA-associated interstitial lung disease (RA-ILD) and pulmonary emphysema, began taking tocilizumab. Subsequently, he developed dyspnea parallel to improvement of RA. At 10 months after the administration of tocilizumab, he was urgently admitted because of exacerbation of ILD. He died despite receiving steroid pulse therapy and antibiotic therapy on a respirator. This is the first case report to describe the exacerbation of ILD during treatment with tocilizumab in the postmarketing surveillance (PMS) period.

• 出版日期2012-12