A study of structural differences between TBM patients' and non-TBM persons' CSF using UV-Vis absorption spectroscopy

作者：Xu, Fangcheng; Wang, Xin; Xu, Huajia; Wang, Kai^*

来源：Journal of Molecular Structure, 2016, 1103: 183-186.

DOI：10.1016/j.molstruc.2015.09.028

• TBM
• Central nervous infections
• CSF
• UV-Vis absorption spectroscopy
• Diagnosis

Tuberculous meningitis (TBM) is a very common infectious disease in the central nervous system. The delay of diagnosing and treating TBM will lead to high disability and mortality of TBM. Hence, it is very important to promptly diagnose TBM early. In this work, we proposed a new method for diagnosing TBM with CSF samples by using UV-Vis absorption spectroscopy. CSF samples from TBM patients and non-TBM persons were compared, and the sensitivity, specificity, accuracy, positive predictive value reached 83.6%, 69.8%, 77.2%, 76.1% respectively. Our work indicated investigation of CSF using UV-Vis absorption spectroscopy might become a potentially useful method for TBM diagnosis.

• 出版日期2016-1-5
• 单位安徽医科大学