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摘要
Objective: The present study aims to investigate the association of unipolar depression (UPD) with six serotonergic gene polymorphisms in Han Chinese.
Methods: One hundred and thirty-two UPD patients and 180 healthy controls were genotyped for polymorphisms of six serotonergic genes, including tryptophan hydroxylase (TPH1 A218C), serotonin transporter promoter region (5-HTTLPR), serotonin receptor 2A (5-HT(2A)R -1438G/A), serotonin receptor 2C (5-HT(2C)R Cys23Ser), serotonin receptor 6 (5-HT(6)R C267T) and serotonin receptor 1D beta (5-HT(1D beta)R T371G). Symptomatic clusters were evaluated by the 24-item Hamilton Rating Scale for Depression (HAMD).
Results: The frequencies of S/S genotype and S allele in 5-HTTLPR polymorphism were significantly higher in UPD patients than in healthy controls. There was a significant difference in distributions of genotypes in 5-HT(2C)R Cys23Ser polymorphism between UPD patients and control subjects, but the difference became no significant when the data were further stratified by gender. The patients with genotypes G/G and T/G of 5-HT(1D beta)R T371G polymorphism had significantly lower scores of diurnal variation evaluated by HAMD than those with genotype T/T, while the patients with genotype T/G had significantly higher scores of hopelessness than those with genotypes G/G and T/T. There were no significant differences in genotypic and allelic distributions of TPH1 A218C, 5-HT(2A)R -1438G/A or 5-HT(6)R C267T polymorphisms between the case and control groups.
Conclusions: The study demonstrates that 5-HTTLPR and 5-HT(2C)R Cys23Ser polymorphisms might contribute to susceptibility of UPD, and the genotype T/T in 5-HT(1D beta)R T371G polymorphism might be a risk factor for diurnal variation, while T/G might be a protective factor against hopelessness in Han Chinese populations.
- 出版日期2008-6
- 单位哈尔滨医科大学
