Amygdala Na(+), kindling induces upregulation of mRNA for NKCC1, a Na(+), K(+)-2Cl(-) cotransporter, in the rat piriform cortex

作者：Okabe A^*; Ohno K; Toyoda H; Yokokura M; Sato K; Fukuda A

来源：Neuroscience Research, 2002, 44(2): 225-229.

DOI：10.1016/S0168-0102(02)00093-7

• epilepsy
• NKCC
• KCC
• ClC
• chloride
• GABA

GABA, the main inhibitory neurotransmitter in the brain, elicits a hyperpolarizing response by activation of the GABA(A)-receptor/chloride-channel complex under conditions of normal Cl(-) homeostasis. Thus the pathogenesis of epilepsy could involve an impairment of GABA(A)-receptor-mediated inhibition due to a collapse of the Cl(-) gradient. We examined the expression patterns of Cl(-) transporters and a Cl(-) channel in a rat amygdala-kindling model. Activity-dependent increases were observed in the mRNA for NKCCl, an inwardly-directed Cl(-) transporter, in the piriform cortex. This suggests that an increase in [CL(-)](i) and a resultant reduction in GABAergic inhibition may occur in the kindled piriform cortex.

• 出版日期2002-10