A novel construction of quino-fused tropone skeleton: first synthesis of 12H-benzo[4,5]cyclohepta[1,2-b]quinolin-12-one derivatives

作者：Gao Wentao^*; Xing Xueda; Li Yang; Lan Shuai

来源：Tetrahedron, 2014, 70(12): 2180-2189.

DOI：10.1016/j.tet.2014.01.049

• Quinoline
• Tropone
• Polyphosphoric acid
• Intramolecular Friedel-Crafts acylation
• One-pot synthesis

In the present investigation, the incorporation of both quinoline moiety and tropone ring in a molecule frame work in fused form leading to a series of structurally novel and biologically intriguing quinoline/tropone hybrids 12H-benzo[4,5]cyclohepta[1,2-b]quinolin-12-one derivatives has been first achieved through a simple, and economical two-step procedure, involving the one-pot synthesis of (E)-2-(arylvinyl)quinoline-3-carboxylic acids followed by intramolecular Friedel-Crafts acylation reaction using polyphosphoric acid (PPA).

• 出版日期2014-3-25
• 单位渤海大学