MicroRNAs in chronic lymphocytic leukemia

作者：Ward Brian P; Tsongalis Gregory J; Kaur Prabhjot^*

来源：Experimental and Molecular Pathology, 2011, 90(2): 173-178.

DOI：10.1016/j.yexmp.2010.12.002

• MiRNA
• Chronic lymphocytic leukemia
• Pathogenesis

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world. Recent research, conducted primarily in basic science laboratories, has indicated a role for microRNAs (miRNAs) in the pathogenesis and prognosis of this disease. MiRNAs are small, non-coding, functional RNAs, that mediate post-transcriptional inhibition of messenger RNAs. Because miRNA expression levels in CLL patients differ from that of normal patients, there may be a role for these novel small molecules as biomarkers in this disease.

• 出版日期2011-4