A regio- and stereoselective three-component synthesis of 5-( trifluoromethyl)-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidine derivatives under solvent-free conditions

作者：Rahmati Abbas^*

来源：Chemical Papers, 2011, 65(4): 536-541.

DOI：10.2478/s11696-011-0034-1

• fluorinated compounds
• 1,2,4-triazol-3-amine
• solvent-free
• catalyst-free

An efficient one-pot method for regio- and stereoselective synthesis of 5-(trifluoromethyl)-4,5,6,7-tetrahydro-[1,2,4] triazolo[1,5-a]pyrimidines under solvent-free and catalyst-free conditions has been developed. The method involves employing a three-component condensation reaction of an aromatic aldehyde and ethyl 4,4,4-trifluoro-3-oxobutanoate or 1,1,1-trifluoropentane-2,4-dione in the presence of 1,2,4-triazol-3-amine at 90 degrees C.

• 出版日期2011-8