Microarrays as biomarkers in trauma

作者：Bogner V^*; Mutschler W

来源：Unfallchirurg, 2014, 117(8): 686-692.

DOI：10.1007/s00113-013-2540-9

• Inflammatory reaction, posttraumatic systemic
• Gene expression
• Organ dysfunction
• Trauma medicine
• Complexity, biological

The traditional hypothesis-driven scientific approach cannot so far sufficiently elucidate complex pathophysiologies, such as posttraumatic systemic inflammation and subsequent multiple organ failure. This complex system includes different biological and functional levels, the genome, the transcriptome, the proteome, the biome (cells), the organs and finally the whole organism.
Microarray techniques enable a simultaneous search for these different biological levels and their functional relationships on a large scale and to discover new functional pathways and networks and potentially new biomarkers for different pathologies. Microarray technologies lead to a new paradigm in science, the hypothesis-generating approach.
This article reviews important microarray findings in trauma and systemic inflammation research and discusses potentials and limitations of these biotechnological screening methods.

• 出版日期2014-8