Advances in the understanding of the Fc gamma receptors-mediated autoantibodies uptake

作者：Lisi Sabrina; Sisto Margherita; Lofrumento Dario Domenico; D'Amore Simona; D'Amore Massimo^*

来源：Clinical and Experimental Medicine, 2011, 11(1): 1-10.

DOI：10.1007/s10238-010-0098-1

• Autoantibodies
• Fc gamma Receptors
• IgG
• Adalimumab
• Salivary gland

Receptors for the Fc fragment of immunoglobulin G (Fc gamma Rs) are important molecules not only to mediate and control the effectors' functions of IgG antibodies, but they also control the autoimmunity-tolerance balance in the periphery. In humans, three different types of Fc gamma Rs, belonging to the Ig gene superfamily, have been identified; Fc gamma RI (cluster of differentiation (CD64), Fc gamma RII (CD32) and Fc gamma RIII (CD16). A wide range of inflammatory and autoimmune diseases, such as vasculitis, glomerulonephritis, and autoimmune hemolytic anemia, seems to be mediated, in part, by Fc gamma Rs. Recent findings supposed that, under certain conditions, Fc gamma Rs are involved in the penetration of antibodies into cells and Fc gamma Rs constitute one of the main effector mechanisms through which autoantibodies exert their action. In this review, we concentrate on the role of human Fc gamma Rs in autoantibodies penetration and summarize the current knowledge on the structure, ligand binding capacity and their role in autoimmunity and pathogenic effect of autoantibodies.

• 出版日期2011-3